Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury
نویسندگان
چکیده
Ryuji Hataishi, Ana Clara Rodrigues, Tomas G. Neilan, John G. Morgan, Emmanuel Buys, Sruti Shiva, Rosemary Tambouret, Davinder S. Jassal, Michael J. Raher, Elissa Furutani, Fumito Ichinose, Mark T. Gladwin, Anthony Rosenzweig, Warren M. Zapol, Michael H. Picard, Kenneth D. Bloch,* and Marielle Scherrer-Crosbie* Department of Anesthesia and Critical Care, Cardiovascular Research Center, Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
منابع مشابه
Nitric oxide inhalation improves microvascular flow and decreases infarction size after myocardial ischemia and reperfusion.
OBJECTIVES The purpose of this study was to test if nitric oxide (NO) could improve microvascular perfusion and decrease tissue injury in a porcine model of myocardial ischemia and reperfusion (I/R). BACKGROUND Inhaled NO is a selective pulmonary vasodilator with biologic effects in remote vascular beds. METHODS In 37 pigs, the midportion of the left anterior descending coronary artery was ...
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Introduction: Ischemic Preconditioning (IPC) is the phenomen that happens on the heart by one or several short periods of ischemia followed by reperfusion that improve the postischemic recovery of mechanical function. Ischemic preconditioning (IPC) may protect the heart from ischemia reperfusion injury by nitric oxide formation. This study investigated the effect of ischemic preconditioni...
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Inhaled nitric oxide (NO) has been reported to decrease the infarct size in cardiac ischemia-reperfusion (I/R) injury. However, reactive nitrogen species (RNS) produced by NO cause myocardial dysfunction and injury. Because H₂ is reported to eliminate peroxynitrite, it was expected to reduce the adverse effects of NO. In mice, left anterior descending coronary artery ligation for 60 min followe...
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BACKGROUND Prolonged breathing of nitric oxide reduces myocardial ischemia-reperfusion injury, but the precise mechanisms responsible for the cardioprotective effects of inhaled nitric oxide are incompletely understood. METHODS The authors investigated the fate of inhaled nitric oxide (80 parts per million) in mice and quantified the formation of nitric oxide metabolites in blood and tissues....
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OBJECTIVE Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer's disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model of myocardial ischemia and reperfusion. METHODS AND RESULTS Male C57BL6/J mice (8 to 10 week old) were subjected to 45 minutes of left coronary artery ...
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